Studies on the Mechanism of Aldehyde Oxidase and Xanthine Oxidase
نویسندگان
چکیده
منابع مشابه
P-91: Vitamin E and Selenium Supplementation Affects Aldehyde Oxidase, Xanthine Dehydrogenase/Oxidase Activities In Diabetic Rat Ovaries
Background Any factor like diabetes that changes the oxidant/antioxidant balance in favor of oxidants could possibly disrupt the physiologic function of ovaries. So, we have investigated the effect of vitamin E and Se supplements on antioxidant defense in ovaries of diabetic rats with focus on Xanthine dehydrogenase/oxidase (XDH/XO) and Aldehyde oxidase (AO) activities. MaterialsAndMethods This...
متن کاملStudies on the mechanism of action of xanthine oxidase.
Recent studies of the reaction mechanism of the molybdenum-containing enzyme xanthine oxidase are presented. The pH-dependence of both the steady-state and rapid reaction kinetics of the enzyme exhibits is bell-shaped, with pK(a)s for the acid and alkaline limbs of 6.6 and 7.4, respectively. These are assigned to ionizations of an active site base and substrate, respectively, with the implicati...
متن کاملTowards the reaction mechanism of xanthine oxidase from EPR studies.
Introduction EPR was the first spectroscopic method other than UV/visible spectroscopy to be applied systematically to investigations of the structure and functioning of metalloenzymes. The first such EPR studies of xanthine oxidase were reported in 1959 [l]. Since one reduced state of each of the four redox-active centres in the molecule is EPRactive, there is obviously considerable potential ...
متن کاملRole of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of Purine-Related Drugs
Purines are natural compounds that are found in all of the body's cells. They are the most widely distributed kind of N-heterocyclic substances in nature. Purines provide part of the chemical structure of some important co-enzymes and the genes of plants and animals. These compounds also participate in membrane signal transduction, translation and protein synthesis and in the form of purine nuc...
متن کاملThe mechanism of action of xanthine oxidase.
The changes in optical and EPR spectra observed during the anaerobic titration of xanthine oxidase with dithionite can be accounted for by simple oxidation-reduction equilibria involving Mo(VI) u MO(V) H Mo(IV); FAD cf FADH. ++ FADH2, and the l-electron reduction of each of the two ironsulfur centers. The equilibrium constants so obtained permit the calculation of the relative probabilities of ...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2008
ISSN: 0022-3263,1520-6904
DOI: 10.1021/jo801053u